| 摘要 |
Described herein are sterile vessels, as for pharmaceutical use, wherein there is disposed about a primary closure partially protuberant from the vessel a secondary closure resistive of non-destructive disengagement. The secondary closure, which is preferably heat shrunk about the vessel neck and primary closure, is provided with an attenuated fracture zone to facilitate opening. The invention finds application, e.g. in multicompartment mixing vials wherein the primary closure serves as a piston plug which, when activated, unseats a divider plug separating compartments containing medicaments or the like which are accordingly permitted to mix.
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