VERFAHREN ZUR HERSTELLUNG VON NEUEN 1,1 -DISUBSTITUIERTEN OCTAHYDROINDOLO (2,3-A) CHINOLIZINEN, IHREN SALZEN UND OPTISCH AKTIVEN ISOMEREN

摘要

The invention relates to new indolo-quinolizidine derivatives of the general formula (I) or salts or optically active isomers thereof, (I) wherein R stands for an alkyl group, and pharmaceutical compositions containing the same, as well as to a process for the preparation thereof. The new compounds according to the invention possess vasodilatating and hypotensive effects and can be used in the therapy as medicines. The new compounds according to the invention are completely devoid of harmful side-effects The compounds of the general formula (I), or their salts or optically active isomers, respectively, are prepared according to the invention as follows: a compound of the general formula (IV), (IV) wherein R stands for an alkyl group, or a salt thereof is