发明名称 |
Process for the preparation of liposomes |
摘要 |
Synthetic liposomes, for example containing a biologically active substance, are prepared by dispersing a first aqueous liquid with the aid of ultrasonic vibration in a water-immiscible carrier liquid less dense than water in the presence of a compound of the formula XY where X is a hydrophilic polar group and Y is a hydrophobic non-polar group to form dispersed globules of the first aqueous liquid each bounded by a monomolecular layer of the compound XY; adding this dispersion to a second aqueous liquid to form a two layer system separated and bounded by a monomolecular second layer of the compound XY and then centrifuging the system to force the dispersed globules through the second boundary layer of the compound XY and into the second aqueous liquid.
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申请公布号 |
US4089801(A) |
申请公布日期 |
1978.05.16 |
申请号 |
US19760648040 |
申请日期 |
1976.01.12 |
申请人 |
BATTELLE MEMORIAL INSTITUTE |
发明人 |
SCHNEIDER, MICHEL |
分类号 |
A61K9/127;B01F17/14;(IPC1-7):B01J13/02 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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