发明名称 |
PHOSPHOLIPID- OR LIPID-LINKED GLYCOSAMINOGLYCAN, PROCESS FORPRODUCING THE SAME AND METASTASIS INHIBITOR |
摘要 |
This invention relates to compounds prepared by linking glycosaminoglycan to phospholipid or lipid, which are expected to exert a pharmacological effect for inhibiting metastasis because of their excellent function to inhibit adhesion of cancer cells to blood vessel endothelial cells and extracellular matrix. This phospholipid- or lipid-linked glycosaminoglycan can be produced for example by: cleaving and oxidizing reducing terminal group of glycosaminoglycan, and allowing an aldehyde group or a lactone compound of the thusformed derivative or a carboxyl group in the glycosaminoglycan chain to react with a primary amino group of a phospholipid; or linking a glycosaminoglycan derivative to a phospholipid or a lipid by allowing a primary amino group of the derivative to react with a carboxyl group of the phospholipid or lipid. This phospholipidor lipid-linked glycosaminoglycan is useful as a metastasis inhibitor because it has no toxicity.
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申请公布号 |
CA2067211(A1) |
申请公布日期 |
1992.01.25 |
申请号 |
CA19912067211 |
申请日期 |
1991.07.24 |
申请人 |
SEIKAGAKU CORPORATION |
发明人 |
SAKURAI, KATSUKIYO;SUGIURA, NOBUO;KIMATA, KOJI;SUZUKI, SAKARU |
分类号 |
C08B37/00;(IPC1-7):C08B37/00;A61K31/725 |
主分类号 |
C08B37/00 |
代理机构 |
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主权项 |
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地址 |
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