| 发明名称 | Compositions and methods for treating proliferative disorders | ||
| 摘要 | The present invention relates to methods of treating proliferative disorders, particularly immunoproliferative and autoimmune disorders, and methods of producing antibodies which bind NK cell receptors for use in therapeutic strategies for treating such disorders, particularly to deplete cells involved in the immunoproliferative pathology. | ||
| 申请公布号 | US9447185(B2) | 申请公布日期 | 2016.09.20 |
| 申请号 | US200612089314 | 申请日期 | 2006.10.13 |
| 申请人 | INNATE PHARMA, S.A.;UNIVERSITY OF GENOVA;NOVO NORDISK A/S | 发明人 | Romagne Francois;Moretta Alessandro;Blery Mathieu;Spee Petrus Johannes Louis;Morch Ulrik |
| 分类号 | A61K39/395;A61K39/00;A61K39/38;C07K16/28 | 主分类号 | A61K39/395 |
| 代理机构 | LeClairRyan, A Professional Corporation | 代理人 | Teskin Robin L.;LeClairRyan, A Professional Corporation |
| 主权项 | 1. A method of treating a patient with ulcerative colitis, Crohn's disease, psoriasis, or spondyloarthropathy, comprising: administering to said patient a therapeutically effective amount of one or more antibodies that each specifically binds to a receptor selected from KIR2DL1, KIR2DS1, KIR2DL2, KIR2DL3, KIR2DS4, and KIR3DL2 expressed on a T cell and/or a NK cell, wherein the one or more antibodies each comprises an Fc region of the human IgG1 or human IgG3 isotype capable of binding to CD16. | ||
| 地址 | Marseilles FR | ||