摘要 |
Progestationally active steroids may be prepared by first reacting 4-active group substituted C/D trans indanones with substituted beta -keto esters followed by cyclization to B,C,D-tricyclics having an A ring precursor group and then finally forming the desired steroid. Preferred beta -keto esters for this purpose have the formula WHERE R7 is lower alkyl; R15 is oxo, lower alkylene-dioxy, arylenedioxy or (hydrogen and lower alkoxy); B is lower alkoxy-carbonyl-methylene, aryloxy-carbonyl-methylene, cyano-methylene, lower alkyl sulfinyl-methylene, and lower alkyl sulfonyl-methylene; and R25 and R26 are independently selected from the group consisting of hydrogen, hydroxyl and lower alkyl.
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