| 摘要 |
1526367 Nona- and decapeptides IMPERIAL CHEMICAL INDUSTRIES Ltd 19 May 1977 [12 Oct 1976] 42318/76 Heading C3H A polypeptide of Formula (I):-H - pyroglu - A - Trp - Ser - Tyr - D - Phe - Leu - Arg - Pro - Azgly - NH 2 wherein A is D - Phe, D - Trp or a direct bond; and the pharmaceutically-acceptable and veterinarily-acceptable acid addition salts thereof. Polypeptides (I) exemplified are:-H - Pyroglu - D - Phe - Trp - Ser - Tyr - D - Phe - Leu - Arg - Pro - Azgly - -NH 2 ; H - Pyroglu - D - Trp - Trp - Ser - Tyr - D - Phe - Leu - Arg - Pro - Azgly- NH 2 ; H - Pyroglu - Trp - Ser - D - Phe - Leu - Arg - Pro - Azgly - NH 2 . Peptide intermediates isolated are:- HEXAPEPTIDES:-Z - Tyr(Bzl) - D - Phe - Leu - Arg(NO 2 ) - Pro - Azgly - NH 2 ; H - Tyr - DPhe - Leu - Arg(H<SP>+</SP>) - Pro - Azgly - NH 2 . TETRAPEPTIDES:-H - Pyroglu - D - Phe - Trp - Ser - OMe,NHNH 2 and N 3 ; H - Pyroglu - D - Trp - Trp - Ser - OMe,NHNH 2 and N 3 . TRIPEPTIDES:-Boc and H - Arg(NO 2 ) - Pro - Azgly - NH 2 ; Z - Tyr(Bzl) - D - Phe - Leu - OMe,NHNH 2 and N 3 ; Z and H - D - Phe - Trp - Ser - OMe; Z and H - D - Trp - Trp - Ser - OMe; H - Pyroglu - Trp - Ser - OMe,NHNH 2 and N 3 . DIPEPTIDES:-Z and H - Pro - Azgly - NH 2 ; Z and H - D - Phe - Leu - OMe; Z and H - Trp - Ser - OMe. Pharmaceutical or veterinary compositions, which may be in a form of oral or parenteral administration, comprise polypeptide (I) in admixture with a pharmaceutically-acceptable or veterinarily-acceptable diluent or carrier therefor.
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