Purification process for lipopeptides

摘要

The present invention provides simple, cost effective, rapid, and scalable at industrial scale and provide high purity and yield of Echinocandin-type compounds at low cost as compared to prior art. Moreover the process allows for the removal of impurities by using economical salt-adsorbent complex and provide highly purified Echinocandin type compounds which is highly improved in terms of purity and sufficient for further processing to obtain an active pharmaceutical ingredient such as, the antifungals caspogungin, anidulafungin, and micafungin.

主权项

1. A process for the purification of lipopeptides comprising binding the lipopeptides on a salt adsorbent, wherein the salt adsorbent is prepared from phosphate and at least one cation and wherein the lipopeptides are of Echinocandin or Echinocandin type compounds.