摘要 |
1,199,356. Oxytetracycline. ANKERFARM S.p.A. 8 March, 1968 [10 March, 1967], No. 11526/68. Heading C2A. Oxytetracycline is produced in a conventional manner by culturing streptomyces BS/1943 (deposited at the Centraalbureau voor Schimmelcultures, Baarn, under C.B.S. 50266) in a nutrient medium, preferably under submerged aerobic conditions. A typical production medium contains maize starch, maize flour, lucern flour, Zea mais filtrate, soybean flour, (NH 4 ) 2 SO 4 , NH 4 Cl, MnSO 4 , CoCl 2 , KH 2 PO 4 , ZnSO 4 , FeSO 4 , CaCO 3 , SrCO 3 , pork fat and water. The oxytetracycline may be isolated from the culture broth using the method described in U.S.A. Specification 3,272,862. Specification 684,417 is referred to. |