发明名称 |
ARYL-SUBSTITUTED CYCLIC SIRTUIN MODULATORS |
摘要 |
<p>ABSTRACT Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.</p> |
申请公布号 |
WO2006094248(A1) |
申请公布日期 |
2006.09.08 |
申请号 |
WO2006US07778 |
申请日期 |
2006.03.03 |
申请人 |
SIRTRIS PHARMACEUTICALS, INC.;MILBURN, MICHAEL;MILNE, JILL;NORMINGTON, KARL, D. |
发明人 |
MILBURN, MICHAEL;MILNE, JILL;NORMINGTON, KARL, D. |
分类号 |
C07D207/16;A61K31/401;A61K31/4025;A61P9/00;C07D409/04;C07D409/14;C07D487/04 |
主分类号 |
C07D207/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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