发明名称 |
PREPARATION OF PREGELATINIZED HIGH AMYLOSE STARCH AND DEBRANCHED STARCH USEFUL AS AN EXCIPIENT FOR CONTROLLED RELEASE OF ACTIVE AGENTS |
摘要 |
A process is disclosed for the manufacture of an excipient useful for the controlled release of an active agent. In this process, a starting material cons isting of starch or high amylose starch is subjected to a gelatinization in an aqueous med ium. When the starting material consists of starch having an amylose content of less than 50% by weight, the gelatinized material is subjected to an enzymatic debranching treatment so as to obtain a gelatinized debranched starch having a short amylose chain content of at least 50% by weigh. When the starting material consists of s tarch having an amylose content of at least 50% by weight or of a high amylose starch having an amylose content up to 80% by weight, the gelatinized material is optionally subjected to an enzymatic debranching treatment so as to obtain a gelatinized debranched starch having a short amylose chain content of 20% to 50% by weight. The so obtained gelatinized and optionally debranched starch is furth er subjected to a thermal dehydration in order to obtain the requested excipient in form of a powder. Also disclosed is a dosage administration form for the sustained re lease of one or more active agents in the form of a powder. This form which is prefera bly a tablet, comprises the active agent(s) in admixture with the above excipient in s uch an amount as to achieve the requested sustained release.
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申请公布号 |
CA2211778(A1) |
申请公布日期 |
1999.02.14 |
申请号 |
CA19972211778 |
申请日期 |
1997.08.14 |
申请人 |
9068-3293 QUEBEC INC. |
发明人 |
CARRIERE, FRANCOIS;DUMOULIN, YVES |
分类号 |
A61K9/20;A61K9/22;C08B30/14;C08B30/20;(IPC1-7):A61K47/36;A61K9/14;C12S3/12 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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