1-phenylalkyl-1,2,3,6-tetrahydropyridiner til behandling af Alzheimers sygdom

摘要

PCT No. PCT/FR97/02286 Sec. 371 Date Jul. 27, 1999 Sec. 102(e) Date Jul. 27, 1999 PCT Filed Dec. 12, 1997 PCT Pub. No. WO98/25903 PCT Pub. Date Jun. 18, 1998The invention relates to compounds of the formula in which: Y is -CH- or -N-; R1 is hydrogen, a halogen or a CF3, (C1-C4)alkyl or (C1-C4)alkoxy group; R2 is a methyl or ethyl group; R3 and R4 are each hydrogen or a (C1-C3)alkyl; and X is: (a) a (C1-C6)alkyl, a (C1-C6)alkoxy, a (C3-C7)carboxyalkyl, a (C1-C4)alkoxy-carbonyl(C1-C6)alkyl, a (C3-C7)carboxyalkoxy or a (C1-C4)alkoxycarbonyl-(C1-C6)alkoxy; (b) a radical selected from (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C3-C7)-cycloalkylmethyl, (C3-C7)cycloalkylamino and cyclohexenyl, it being possible for said radical to be substituted by a halogen, hydroxyl, (C1-C4)-alkoxy, carboxyl, (C1-C4)alkoxycarbonyl, amino or mono- or di-(C1-C4)-alkylamino; or (c) a group selected from a phenyl, phenoxy, phenylamino, N-(C1-C3)alkyl-phenylamino, phenylmethyl, phenylethyl, phenylcarbonyl, phenylthio, phenylsulfonyl, phenylsulfinyl and styryl, it being possible for said group to be monosubstituted or polysubstituted on the phenyl group by a halogen, CF3, (C1-C4)alkyl, (C1-C4)alkoxy, cyano, amino, mono- or di-(C1-C4)alkyl-amino, (C1-C4)acylamino, carboxyl, (C1-C4)alkoxycarbonyl, aminocarbonyl, mono- or di-(C1-C4)alkylaminocarbonyl, amino(C1-C4)alkyl, hydroxy(C1-C4)alkyl or halogeno(C1-C4)alkyl; to a method of preparing them and to the pharmaceutical compositions containing them. These compounds have neurotrophic and neuroprotective activity.