COMPOSITION COMPRISING ROD-SHAPED NANOPARTICLES AND NUCLEIC ACID

摘要

The present invention addresses the problem of providing a composition comprising nanoparticles and nucleic acid, the composition having an enhanced adjuvant effect. The present invention provides a composition comprising rod-shaped nanoparticles and nucleic acid. Examples of preferred rod-shaped nanoparticles include particles made of gold, platinum, silver, titanium oxide, silica, silicon, biodegradable polymers, and other such materials, the particles having a short-axis length of 4-20 nm and a long-axis length 2-20 times the short-axis length. Examples of preferred nucleic acids include double-stranded ribonucleic acid having a weight-average chain length within a range of 0.1-2.0 kbp. In a preferred embodiment, the composition contains complexes of rod-shaped nanoparticles and nucleic acid.