VARIABLE MASS LABELING REAGENTS AND ANALYTICAL METHODS FOR SIMULTANEOUS PEPTIDE SEQUENCING AND PROTEIN QUANTITATION USING THEREOF

摘要

PURPOSE: A variable mass labeling agent is provided to ensure qualification signal in different mass value. CONSTITUTION: A variable mass labeling agent has a structure of chemical formula 1. In chemical formula 1, R_S or R_B, or R_S and R_B are straight or branched C1-C18 alkyl, and R_T is mass regulation group. Linker is a reactive linker which induces the bond with analyte. The reactive linker is an active ester.