4-aminothiazole derivatives and their use as inhibitors of cyclin-dependent kinases

摘要

A compound of formula (I), wherein: R1 is an optionally substituted group selected from alkyl ; alkenyl; alkynyl; alkoxyl; alcohol; carbocyclic or heterocyclic, monocyclic or fused or nonfused polycyclic, cycloalkyl; carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, aryl; carbonyl; ether; alkylcarbonyl; alkylaryl; alkylcycloalkyl; alkylalkoxyl; arylalkoxyl; thioether; thiol; and sulfonyl; wherein when R1 is substituted, each substituent independently is a halogen; haloalkyl; alkyl; alkenyl; alkynyl; hydroxyl; alkoxyl; amino; nitro; thiol; thioether; imine; cyano; amido; phosphonato; phosphine; carboxyl; thiocarbonyl; sulfonyl; sulfonamide; ketone; aldehyde; ester; oxygen; carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, cycloalkyl; or carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, aryl. R2 is a carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, ring structure having a substituent at the position adjacent to the point of attachment, which ring structure is optionally further substituted, where each substituent of R2 independently is a halogen; haloalkyl; alkyl ; alkenyl; alkynyl ; hydroxyl; alkoxyl; amino; nitro; thiol; thioether; imine; cyano; amido; phosphonato; phosphine; carboxyl; thiocarbonyl; sulfonyl; sulfonamide; ketone; aldehyde; ester; oxygen; carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, cycloalkyl; or carbocyclic or heterocyclic, monocyclic or fused or nonfused polycyclic, aryl. With the proviso that R1 is not selected from the groups (II). Also described is a pharmaceutical composition comprising the compound of formula (I) together with a pharmaceutically acceptable carrier. The compounds of formula (I) are useful for the inhibition of CDK4 or a CDK4/cyclin complex.