Lactam glycogen phosphorylase inhibitors and method of use

摘要

A compound of formula I wherein W is a bicyclic hetroaryl of the structure X is -O-, -S-, -SO₂-, -CHR⁵-, -CHR⁵O-, -CHR⁵S-, -CHR⁵SO₂-, -CHR⁵CO- or -CH₂CHR⁵-; Y is a bond or -CHR⁶-; Z is an aryl or heteroaryl group of the following structure: A is -CH- or -N-; B is -O- or -S-; and R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ are as described herein. Further provided is a method for treating diabetes and related diseases employing a glycogen phosphorylase inhibiting amount of the above compound, either alone or in combination with another therapeutic agent.