发明名称 |
Process for the preparation of isothiazolinones by cyclisation. |
摘要 |
<p>Compounds of the general formula <CHEM> are cyclised to the corresponding isothiazolinone using a carbonyl halide of the formula RCOX where R is halogen or alkyl and X is halogen. R<3> and R<4> are preferably such as to form a 5 or 6 membered ring. Useful carbonyl halides are phosgene and propionyl chloride. Using acyl halides such as propionyl chloride, a mixture of the isothiazolinone and a salt of the carboxylic acid can be obtained, for example an essentially equimolar mixture of 2-methyl-4,5-trimethyl-4-isothiazolin-3-one and sodium propionate.</p> |
申请公布号 |
EP0419075(A2) |
申请公布日期 |
1991.03.27 |
申请号 |
EP19900309576 |
申请日期 |
1990.08.31 |
申请人 |
IMPERIAL CHEMICAL INDUSTRIES PLC |
发明人 |
MOFFATT, FRANK SUTOR;WINSTANLEY, DAVID |
分类号 |
A01N43/78;C07D275/02;C07D275/03;C07D275/04 |
主分类号 |
A01N43/78 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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