| 摘要 |
FIELD: biochemistry, medicine, allergology. ^ SUBSTANCE: invention relates to a method for preparing the hypoallergic birch pollen basic allergen r Bet v 1. Method involves one or more steps of chromatography purification using essentially non-buffered aqueous bases as an eluent and the following neutralization. Hypoallergic basic allergens from birch pollen distinct by absence or decreased binding of immunoglobulin E and simultaneous retaining therapeutically relevant stimulation of T cells. Therefore, prepared preparation can be used as a therapeutic agent with reduced adverse effects for carrying out the specific immunotherapy. ^ EFFECT: improved and valuable properties of allergen, improved preparing method. ^ 27 cl, 6 dwg, 1 tbl, 6 ex |
