| 摘要 |
<p>A method of preparing di 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (tetramisole) and acid addition salts thereof, by reacting di 3-( beta -hydroxyphenethyl)-2-iminothiazolidine with a highly concentrated aqueous hydrochloric acid at moderately elevated temperatures to obtain the di 3-( beta -chlorophenethyl)-2-iminothiazolidine acid-addition salt, converting the latter compound to di 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole which is converted to di 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole acid addition salt in a highly purified state. The products are useful as anthelmintics.</p> |
