| 发明名称 | Methods for controlling the galactosylation profile of recombinantly-expressed proteins | ||
| 摘要 | The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose. | ||
| 申请公布号 | US9365645(B1) | 申请公布日期 | 2016.06.14 |
| 申请号 | US201615014694 | 申请日期 | 2016.02.03 |
| 申请人 | AbbVie, Inc. | 发明人 | Bengea Cornelia;Rives Lisa M.;Hossler Patrick |
| 分类号 | A61K39/00;C07K16/24 | 主分类号 | A61K39/00 |
| 代理机构 | McCarter & English, LLP | 代理人 | McCarter & English, LLP ;Zacharakis Maria Laccotripe |
| 主权项 | 1. A composition comprising an antibody comprising the heavy and light chain variable domains of adalimumab, wherein less than 70% of the total N-linked oligosaccharides present on said antibody are of an agalactosyl fucosylated biantennary oligosaccharide form (sum NGA2F+NGA2F-GlcNAc). | ||
| 地址 | North Chicago IL US | ||