(R)-5-BROMO-N-(1-ETHYL-4-METHYLHEXAHYDRO-1H-1,4-DIAZEPIN-6-YL)-2-METHOXY-6-METHYLAMINO-3-PYRIDINE-CARBOXAMIDE, PROCESS FOR PRODUCING THE SAME AND MEDICINAL COMPOSITION CONTAINING THE SAME

摘要

The compound represented by formula (I) and physiologically acceptable acid-addition salts thereof. The compounds have an excellent antiemetic effect based on potent antagonism against serotonin S3 and dopamine D2 receptors and, therefore, are usable as an antiemetic agent in the treatment or prevention of various diseases and many digestive symptoms accompanying the administration of drugs, etc.