| 发明名称 |
TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM |
| 摘要 |
The present invention relates to the treatment of prevention of tinnitus. More precisely, the present invention relates to a compound modulating chloride co-transporter NKCC1 (chloride co-transporter modulator) for use in the treatment of tinnitus. In addition, the present invention concerns pharmaceutical composition comprising such an NKCC1 chloride co-transporter modulator as an active agent a method for the treatment or prevention of tinnitus by administering such a chloride co-transporter modulator, and a screening method for the identification and characterization of compounds capable of modulation chloride co-transporter NKCC1. |
| 申请公布号 |
US2016271098(A1) |
申请公布日期 |
2016.09.22 |
| 申请号 |
US201615166359 |
申请日期 |
2016.05.27 |
| 申请人 |
OTOLANUM AG |
发明人 |
KNIPPER Marlies;RUETTIGER Luckas |
| 分类号 |
A61K31/341;G01N33/50;A61K31/196;A61K45/06;A61K9/00 |
主分类号 |
A61K31/341 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating or preventing tinnitus in a subject in need thereof comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of a compound that modulates sodium potassium chloride co-transporter 1 (NKCC1, wherein the compound decreases NKCC1 expression or activity in auditory sensorineural structures in the subject following administration. |
| 地址 |
ZUG CH |
