| 摘要 |
PROBLEM TO BE SOLVED: To provide sarpogrelate hydrochloride of a crystal form suitable for formulation of a solid pharmaceutical preparation and to provide a method for producing the sarpogrelate hydrochloride of crystal form with good reproducibility and simpler operation in high yield. SOLUTION: The crystal form B of the sarpogrelate hydrochloride having a powder X-ray diffraction spectrum represented as substantially the same in the figure is produced by a method for recrystallization from one kind of solvent or a mixed solvent of two or more kinds thereof selected from the group consisting of acetone, acetonitrile, methanol, ethanol, isopropyl alcohol, N,N-dimethylformamide and tetrahydrofuran or a mixed solvent of the solvents with water. Thereby, the crystal form B is provided. Hydrous acetone or hydrous acetonitrile is preferable in the solvents. The hydrous acetone with 1-10 wt.% moisture content or the hydrous acetonitrile with 1-7 wt.% moisture content is especially preferred. COPYRIGHT: (C)2007,JPO&INPIT
|
