摘要 |
A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites. The compounds of the invention unexpectedly provide a single-dose cure for malaria, as well as prophylactic activity against the same. The compounds are also active against schistosomiasis and cancer. |
申请人 |
MEDICINES FOR MALARIA VENTURE MMV;VENNERSTROM, JONATHAN, L.;DONG, YUXIANG;CHARMAN, SUSAN, A.;WITTLIN, SERGIO;CHOLLET, JACQUES;CREEK, DARREN, J.;WANG, XIAOFANG;SRIRAGHAVAN, KAMARAJ;ZHOU, LIN;MATILE, HUGUES;CHARMAN, WILLIAM, N. |
发明人 |
VENNERSTROM, JONATHAN, L.;DONG, YUXIANG;CHARMAN, SUSAN, A.;WITTLIN, SERGIO;CHOLLET, JACQUES;CREEK, DARREN, J.;WANG, XIAOFANG;SRIRAGHAVAN, KAMARAJ;ZHOU, LIN;MATILE, HUGUES;CHARMAN, WILLIAM, N. |