Antibody constructs for influenza M2 and CD3

摘要

The present invention relates to an antibody construct comprising a first human binding domain specific for the extracellular part of the influenza envelope protein M2 (M2e) and a second domain specific for CD3. Moreover, the invention provides a nucleic acid molecule encoding the antibody construct, a vector comprising said nucleic acid molecule and a host cell transformed or transfected with said nucleic acid molecule or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a pharmaceutical composition comprising said antibody construct, a medical use/method of treatment relating to said antibody construct, and a kit comprising said antibody construct.

主权项

1. An antibody construct comprising:
(a) a first human binding domain comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 1, a CDR-H2 as comprising the amino acid sequence of SEQ ID NO: 2, a CDR-H3 as comprising the amino acid sequence of SEQ ID NO: 3, a CDR-L1 as comprising the amino acid sequence of SEQ ID NO: 4, a CDR-L2 as comprising the amino acid sequence of SEQ ID NO: 5, and a CDR-L3 as comprising the amino acid sequence of SEQ ID NO: 6; and (b) a second binding domain specific for CD3.