MOSAPRIDE SUSTAINED-RELEASE PREPARATION FOR PROVIDING PHARMACOLOGICAL CLINICAL EFFECTS WITH ONCE-A-DAY ADMINISTRATION.

摘要

A preparation for oral administration of the present invention, containing mosapride or salt thereof, is a double-layer preparation consisting of an immediate-release layer which allows drug to be rapidly released, and a sustained-release layer which allows drug to be slowly released, in order to simultaneously satisfy a rapid expression of pharmacological activity and a 24-hour duration of pharmacological activity, and is characterized by controlling a dissolution rate of each site within the gastrointestinal tract with different pHs and/or a residence time in the gastrointestinal tract by using, in a mixed manner, high viscosity hydroxypropyl methylcellulose (HPMC) and low viscosity hydroxypropyl methylcellulose (HPMC) in such a manner that the proportion of high viscosity hydroxypropyl methylcellulose (HPMC), as a release-control base in the sustained-release layer, is higher. Furthermore, the preparation of the present invention has a small size with a total weight of 200 mg or less, preferably 150 to 160 mg, and thus, has the advantage of increasing a patient's medication adherence.