| 摘要 |
PCT No. PCT/US93/04986 Sec. 371 Date Dec. 5, 1994 Sec. 102(e) Date Dec. 5, 1994 PCT Filed May 26, 1993 PCT Pub. No. WO93/24616 PCT Pub. Date Dec. 9, 1993A live, attenuated varicella zoster virus vaccine is produced with enhanced yield of VZV. The new process makes mass production of a live VZV vaccine more practical. In addition, optimized monoloyer cell culture conditions provide a process for maximizing monolayer cell density which is useful for enhancing viral vaccine production. According to this process, cell densities approaching 500,000 cells/cm2 are routinely achieved in conventional culture vessels.
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