发明名称 |
DERIVATION OF HEPATIC STEM CELLS AND MATURE LIVER CELL TYPES AND USES THEREOF |
摘要 |
This application describes liver stem cells (LSC), and differentiated hepatocytes, cholangiocytes, and 3D cellular structures derived therefrom. Methods for producing LSC and mature, differentiated hepatocytes and cholangiocytes in culture are provided. Also provided are cell culture systems and cell culture media for producing a homogenous population of liver stem cells that remain in an undifferentiated state over multiple passages in culture. The LSC and methods are useful for producing homogenous populations of hepatocytes and cholangiocytes for downstream applications. The LSC can be transplanted into subjects to treat liver diseases. |
申请公布号 |
WO2016200340(A1) |
申请公布日期 |
2016.12.15 |
申请号 |
WO2016SG50270 |
申请日期 |
2016.06.10 |
申请人 |
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH;NATIONAL UNIVERSITY OF SINGAPORE |
发明人 |
HU, Yuanyu;NG, Huck Hui;DAN, Yock Young |
分类号 |
C12N5/074;A61K35/407;C12N5/02;C12N5/071 |
主分类号 |
C12N5/074 |
代理机构 |
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代理人 |
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地址 |
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