| 发明名称 |
METHOD FOR TREATING JOINT DAMAGE |
| 摘要 |
Methods of treating joint damage in a subject eligible for treatment are provided involving administering an antagonist that binds to a B-cell surface marker, such as CD20 antibody, to the subject in an amount effective to slow progression of the joint damage as measured by radiography. Further provided are articles of manufacture useful for such methods. |
| 申请公布号 |
US2016176974(A1) |
申请公布日期 |
2016.06.23 |
| 申请号 |
US201615055485 |
申请日期 |
2016.02.26 |
| 申请人 |
Genentech, Inc. ;F. Hoffmann-La Roche AG ;Biogen Inc. |
发明人 |
Totoritis Mark;Shaw Timothy Mark;Agarwal Sunil;Yocum David;Kelman Ariella |
| 分类号 |
C07K16/28;A61K31/519;A61K39/395;A61K47/48;A61K45/06 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating joint damage in a subject comprising administering a CD20 antibody to the subject, and giving the subject, at least about one month after the administration, a radiographic test that measures a reduction in the joint damage as compared to baseline prior to the administration, wherein the amount of CD20 antibody administered is effective in achieving a reduction in the joint damage. |
| 地址 |
South San Francisco CA US |
