| 发明名称 |
DUAL-ACTING BENZOIMIDAZOLE DERIVATIVE AND THEIR USE AS ANTIHYPERTENSIVE AGENTS |
| 摘要 |
<p>The invention relates to compounds having the formula: (I) wherein Ar, r, n, X, R2, R2', R3, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.</p> |
| 申请公布号 |
WO2009076288(A1) |
申请公布日期 |
2009.06.18 |
| 申请号 |
WO2008US85868 |
申请日期 |
2008.12.08 |
| 申请人 |
THERAVANCE, INC.;CHOI, SEOK-KI;FATHEREE, PAUL R.;MCKINNELL, ROBERT MURRAY;OLSON, BROOKE |
发明人 |
CHOI, SEOK-KI;FATHEREE, PAUL R.;MCKINNELL, ROBERT MURRAY;OLSON, BROOKE |
| 分类号 |
C07D235/08;A61K31/4184;A61P9/00;C07D235/26;C07D403/10 |
主分类号 |
C07D235/08 |
| 代理机构 |
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