发明名称 |
WATER- SOLUBLE DERIVATIVES OF LIPOPHILIC DRUGS |
摘要 |
A water-soluble reference standard is useful for immunoassays of a lipophilic drugs. The reference standard is a compound of formula (I): <?in-line-formulae description="In-line Formulae" end="lead"?>G-(L)<SUB>n</SUB>-Y; (I)<?in-line-formulae description="In-line Formulae" end="tail"?> where G is a lipophilic drug; L is a linker which is an alkyl group or heteroalkyl group containing from 1 to 20 carbon atoms; n is 0 or 1; and Y is a water-solubilizing group such as -SO<SUB>3</SUB><SUP>-</SUP>, -NR-SO<SUB>3</SUB><SUP>-</SUP>, -P(-O)(OH)(O<SUP>-</SUP>), or -O-P(-O)(OH)(O<SUP>-</SUP>); where R is H or an alkyl group of 1 to 10 carbon atoms. |
申请公布号 |
EP1468295(A2) |
申请公布日期 |
2004.10.20 |
申请号 |
EP20030731624 |
申请日期 |
2003.01.23 |
申请人 |
ROCHE DIAGNOSTICS GMBH;F. HOFFMANN-LA ROCHE AG |
发明人 |
LI, MIN;WU, ROBERT, S.;TSAI, JANE, S., C. |
分类号 |
G01N33/531;A61K47/48;C07D243/24;C07D243/26;G01N33/53;G01N33/94;(IPC1-7):G01N33/94 |
主分类号 |
G01N33/531 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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