MODIFIED SILICA SHELL PARTICLES, AND METHODS OF MAKING AND USING THE SAME

摘要

Provided herein are silica shell particles modified on their surface with biomolecules, methods of making these particles, and methods of using these particles, e.g., in transfection methods, methods of inhibiting gene expression, and methods of delivering a therapeutic.

主权项

1. A method comprising
a) admixing a nanoparticle and a silica reagent to form a silica shell nanoparticle; b) admixing the silica shell nanoparticle and a biomolecule to attach the biomolecule to at least a portion of the silica shell nanoparticle surface; and c) at least partially removing the nanoparticle to form a biomolecule-surface modified silica shell particle,wherein the biomolecule attaches to the silica shell nanoparticle surface via a cycloaddition adduct.