| 发明名称 |
Stabilized Factor VIII Variants |
| 摘要 |
The present invention relates to modified coagulation factors. In particular, the present invention relates to stabilized Factor VIII molecules conjugated with a half life extending moiety as well as use of such molecules. |
| 申请公布号 |
US2016264645(A1) |
申请公布日期 |
2016.09.15 |
| 申请号 |
US201615170502 |
申请日期 |
2016.06.01 |
| 申请人 |
Novo Nordisk A/S |
发明人 |
Oestergaard Henrik;Kjalke Marianne;Olsen Ole Hvilsted;Thim Lars;Stennicke Henning Ralf |
| 分类号 |
C07K14/755;A61K47/48;A61K38/37 |
主分类号 |
C07K14/755 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A recombinant FVIII variant having FVIII activity and increased in vitro stability, wherein said FVIII variant is conjugated with a half life extending moiety, and, wherein amino acid alterations resulting in increased in vitro stability have been introduced into said FVIII variant. |
| 地址 |
Bagsvaerd DK |
