发明名称 |
PREPARATION OF STABILIZER-FREE GOLD SOLS AND THEIR CONFIGURATION INTO A GELATIN-COATED PROTEASE-INDICATING HOMOGENEOUS (ONE STEP) ASSAY |
摘要 |
A method of detecting protease activity in a sample. The method includes contacting the sample with a composition containing (i) a dispersion of gold nanoparticles, whose surface is coated with a gelatin; and (ii) CaCl2. A color change of the composition, a turbidity change of the composition, or both, upon the contacting of the sample with the composition, indicates the presence of protease activity in the sample. A kit adapted for performing the method. The kit includes (i) a vial containing a composition comprising CaCl2 and a dispersion of gold nanoparticles whose surface is coated with a gelatin; (ii) a cap configured for attachment to the vial, comprising a rubber septum; and (iii) a sampling device configured for collecting a fluid from a wound. |
申请公布号 |
WO2016011323(A8) |
申请公布日期 |
2016.09.15 |
申请号 |
WO2015US40859 |
申请日期 |
2015.07.17 |
申请人 |
KERSCHENSTEINER, Daniel, A.;HAYRE, Paul, N. |
发明人 |
KERSCHENSTEINER, Daniel, A.;HAYRE, Paul, N. |
分类号 |
C12Q1/37;G01N21/78;G01N33/52;G01N33/58 |
主分类号 |
C12Q1/37 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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