发明名称 |
NON-TOXIC TOPICAL ANESTHETIC OPHTHALMIC COMPOSITIONS |
摘要 |
Compositions and methods for prolonging the local anesthetic effect of site 1 sodium channel blockers and local anesthetics with minimal or reduced toxicity have been developed for ophthalmic use. It has been established that agents such as dexmedetomidine having alpha-2-adrenergic agonist and Hyperpolarization-activated cyclic nucleotide-gated channel antagonist activity can dramatically prolong the duration of nerve blockade when administered to the surface of, a compartment of or tissue adjacent to, the eye. A preferred active agent for prolonging the local anesthetic effect of site 1 sodium channel blockers or local anesthetics is Dexmedetomidine. |
申请公布号 |
WO2016100209(A1) |
申请公布日期 |
2016.06.23 |
申请号 |
WO2015US65554 |
申请日期 |
2015.12.14 |
申请人 |
THE CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
KOHANE, DANIEL, S.;MCALVIN, JAMES, B.;ZHAN, CHANGYOU |
分类号 |
A61K9/00;A61K9/127;A61K31/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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地址 |
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