发明名称 |
PURIFICATION AND STABILIZATION OF PEPTIDE AND PROTEINS IN PHARMACEUTICAL AGENTS |
摘要 |
A method is provided for purifying a peptide or a protein comprising: providing a peptide or protein composition containing an impurity to be removed; forming a complex of the active agent with a complexing agent thereby displacing the impurity; and, removing essentially all of the impurity from the complex. A composition is provided comprising such a purified peptide complexed with a complexing agent. Microparticles comprising monomeric or dimeric insulin complexed with a complexing agent, wherein the insulin is substantially free of zinc, may be used in medicine to deliver insulin to a patient. Also provided is a formulation for use in medicine comprising insulin complexed with a complexing agent which, when administered to a patient in an effective amount, produces a peak blood insulin concentration in the patient that simulates a normal response to eating, wherein the formulation is suitable for non-intravenous administration. |
申请公布号 |
EP1808438(A3) |
申请公布日期 |
2008.12.24 |
申请号 |
EP20070075344 |
申请日期 |
2000.06.29 |
申请人 |
MANNKIND CORPORATION |
发明人 |
STEINER, SOLOMON S.;WOODS, RODNEY J.;SULNER, JOSEPH W. |
分类号 |
A61K9/18;C07K1/36;A61K9/00;A61K9/16;A61K38/28;A61K47/00;A61K47/22;A61P3/10;C07D241/08;C07K1/00;C07K1/30;C07K14/605;C07K14/62 |
主分类号 |
A61K9/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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