AN IMPROVED PROCESS FOR THE PREPARATION OF FLUVOXAMINE MALEATE

摘要

The present invention relates to an industrially feasible and economically viable process for the preparation of fluvoxamine maleate of formula I.;

主权项

1. An improved process for the preparation of fluvoxamine maleate of formula I,comprising the steps of:
a). condensing the compound of formula II,  with hydroxylamine hydrochloride in the presence of sodium carbonate granules in suitable solvent to form a compound of formula III; b). isolating compound of formula III; c). treating compound of formula III with 2-chloroethylamine hydrochloride in the presence of base in suitable solvent at 40-45° C. to form compound of formula IV; d). extracting compound of formula IV with suitable solvent to form an organic layer; e). treating organic layer of step d) with maleic acid; f). isolating crude fluvoxamine maleate of formula I; and g). optionally purifying fluvoxamine maleate of formula I.