| 发明名称 |
SINGLE-STEP FUNCTIONALIZATION AND CROSS-LINKING OF HYALURONIC ACID |
| 摘要 |
A process for manufacturing a cross-linked hyaluronic acid (HA) containing a functionalizing group including the step of reacting HA with a mixture of: (i) a first cross-linking agent selected from the group of bifunctional epoxides and polyfunctional epoxides, and (ii) a functionalized agent of a functionalizing group coupled via a 1,2,3-triazole linkage to a second cross-linking agent selected from the group of bifunctional epoxides and polyfunctional epoxides, to obtain a cross-linked HA containing the functionalizing group. The process provides a cross-linked hyaluronic acid (HA) containing a functionalizing group. The process utilizes a functionalized agent of a functionalizing group coupled via a 1,2,3-triazole linkage to a cross-linking agent. |
| 申请公布号 |
US2016237177(A1) |
申请公布日期 |
2016.08.18 |
| 申请号 |
US201415024647 |
申请日期 |
2014.09.30 |
| 申请人 |
GALDERMA S.A. |
发明人 |
BOITEAU Jean-Guy |
| 分类号 |
C08B37/08;A61L27/20;A61L27/50;A61K49/00 |
主分类号 |
C08B37/08 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for manufacturing a cross-linked hyaluronic acid (HA) containing a functionalizing group, comprising a step of reacting HA in a single step with a mixture of:
(i) a first cross-linking agent selected from a group consisting of bifunctional epoxides and polyfunctional epoxides, and (ii) a functionalized agent, consisting of a functionalizing group coupled via a 1,2,3-triazole linkage to a second cross-linking agent selected from the group consisting of bifunctional epoxides and polyfunctional epoxides, to obtain a cross-linked HA containing the functionalizing group. |
| 地址 |
Cham CH |
