Tissue implant

摘要

An implant, artificial or semi-artificial at implantation, for repairing an articular cartilage and osteochondral defect site in a mammalian, such as a human. The implant having at least a first surface and a second surface. The first surface shaped for being press-fitted into the defect site to create an interface between the first surface and a bone-cartilage region of the defect site, and the second surface shaped for being press-fitted into the defect site to create an interface between the second surface and an articular cartilage region of the defect site. The implant being seeded, prior to implantation, with chondroprogenitor cells, including superficial zone chondroprogenitor cells.

主权项

1. An implant, artificial or semi-artificial at implantation, for implantation at an articular cartilage and osteochondral defect site in a human comprising:
a manufactured biocompatible scaffold, the scaffold comprising at least a first surface and a second surface; the first surface shaped to press-fit into the defect site to create an interface between the first surface and a bone-cartilage region of the defect site; the second surface shaped to press-fit into the defect site to create an interface between the second surface and an articular cartilage region of the defect site; a distance d1 between the first and second surfaces; and depth d2 from the second surface, wherein d2 comprises a greater concentration of articular chondroprogenitor cells than the concentration of these cells in the remaining depth of the implant and wherein d2/d1<1.