PROCESS FOR PRODUCING INORGANIC PARTICULATE MATERIAL

摘要

The present invention relates to a process for producing inorganic particulate material, the material obtainable by such process, a modified release delivery system comprising the material and the use of the material for the administration of a bioactive agent.

主权项

1. A process for producing inorganic particulate material mainly composed of silicon oxide, wherein the particulate material comprises mesopores and macropores and the process includes the steps of:
(a) dissolving a water-soluble polymer or another pore forming agent and a precursor for a matrix dissolving agent in a medium that promotes the hydrolysis of the metalorganic compound (see step b); (b) mixing a metalorganic compound or a mixture of metalorganic compounds which contains hydrolyzable ligands to promote hydrolysis reaction; (c) solidifying the mixture through a sol-gel transition, wherein the mixture is continuously stirred, whereby particles are prepared which have three dimensional interconnected phase domains one rich in solvent the other rich in inorganic component in which surface pores are contained; (d) setting the matrix dissolving agent free from its precursor, whereby the matrix dissolving agent modifies the structure of said inorganic component; (e) removing the solvent by evaporation drying and/or heat-treatment.