| 摘要 |
FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to the improved method for preparing water-soluble amino acids derivatives of fullerene that can be used in pharmacology and microbiology. Invention describes method for preparing water-soluble amino acid derivatives of fullerene of the general formula (I): HC60NH(CH2)nCOO-Kt+ wherein C60 is a fullerene ring; Kt+ is hydrogen atom, ammonium or alkaline metal cation; n = 1, 3, 5. Method involves interaction of fullerene with amino acid salt at heating and the following isolation of the end product. Compound of the general formula (II): is used as amino acid salt wherein R is CqH2q+1; m = 3, 4; q = 2-5; ¦- is chemical element taken among (Va) or (VIa) groups of Mendeleyev's periodic system. Then compound of the general formula (III): is prepared wherein R, ¦, n, m have values given above that is subjected for the following reactions: in the case for preparing the end product of the general formula (I) wherein Kt+ is hydrogen atom method involves effect with acid solution and if Kt+ is ammonium or alkaline metal cation method involves effect with corresponding salt. Proposed method does not require the special equipment and can be carried out using the conventional chemical equipment that results to the simplified technological process and reduced cost of the end product. EFFECT: improved preparing method. 4 ex
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