PROCESS FOR PRODUCING SPORIDIOBOLUS RUINENIAE STRAINS WITH IMPROVED COENZYME Q10 PRODUCTION

摘要

A process for producing a mutagenized Sporidiobolus ruineniae strain having a Q10 productivity of greater than 1.38 mg of Q10/g of dry biomass, wherein (a) a Sporidiobolus ruineniae strain is subjected to genetic manipulation by mutagenesis, and (b) the mutagenized Sporidiobolus ruineniae strain is subjected to a selection where the mutagenized Sporidiobolus ruineniae strain is cultivated under conditions which inhibit growth of the Sporidiobolus ruineniae strain employed in (a), the conditions being chosen so that the mutagenized strain overcomes the growth inhibition through a Q10 production which is increased by comparison with the Sporidiobolus ruineniae strain employed in (a), grows in a fermentation medium and (c) is isolated from the fermentation medium.