| 摘要 |
Disclosed is a compound of formula I or a pharmaceutically acceptable salt thereof wherein: n is 0, 1 or 2; p is 1 or 2; R1 is optionally substituted aryl or heteroaryl; R3 is H, alkyl or -C(=O)-R5 where R5 is alkyl, alkoxy, aryl or aryloxy; and each R4 is independently H, OH, CN, alkyl, alkoxy, thioalkyl, alkylthio, halo, haloalkyl, hydroxyalkyl, nitro, alkoxycarbonyl, alkylcarbonyl, alkylsulfonyl, arylsulfonyl, haloalkylsulfonyl, amino, alkylamino, dialkylamino, alkyl(aryl)amino, alkylaminocarbonyl, alkylcarbonylamino, alkycarbonyl(alkylamino), alkylaminosulfonyl, alkylsulfonylamino or methylenedioxy. Compounds of the type disclosed are 5-HT6 agonists useful in the treatment of disorders of the central nervous system.
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