| 摘要 |
Disclosed are compounds having activity as non-covalent inhibitors of urokinase and having activity in reducing or inhibiting blood vessel formation. The compounds are of formula I, wherein X is selected from SO2, NR'SO2, C=O, OC=O, NHC=O, POR' and a direct link, wherein R' is independently hydrogen, alkyl of 1 to about 4 carbon atoms, aryl of about 6 to about 14 carbon atoms or aralkyl of about 7 to about 16 carbon atoms, with the proviso that when X is POR' then R' is not hydrogen, and all other substituents are as described in the specification. These compounds are useful in vitro for monitoring plasminogen activator levels and in vivo in treatment of conditions which are ameliorated by inhibition of or decreased activity of urokinase and in treating pathologic conditions wherein blood vessel formation is related to a pathologic condition.
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