发明名称 HAT ACETYLATION PROMOTERS AND USES OF COMPOSITIONS THEREOF IN PROMOTING IMMUNOGENICITY
摘要 The invention provides processes and compositions for enhancing the immunogenicity of TAP-1 expression-deficient cells by increasing the presentation of MHC Class I surface molecules for detection by cytotoxic T-lymphocyte cells through increased TAP-1 expression, which comprises administering to the TAP-1 expression-deficient cells a TAP-1 expression increasing amount of a bio-acceptable substance that promotes transcription of TAP-1 gene in the cells to cause enhanced MHC Class I surface expression of the cells. The bio-acceptable substance may be a histone H3 deacetylase inhibitor such as trichostatin A, a transcriptional co-activator having intrinsic histone acetyl transferase activity or a histone acetyl transferase comprising at least one member of the CBP/p300 protein family. The process and compositions increase the immunogenicity of the target cells, e.g. tumor cells, to enhance their destruction by cytotoxic lymphocytes.
申请公布号 CA2574531(C) 申请公布日期 2016.10.25
申请号 CA20072574531 申请日期 2007.01.19
申请人 THE UNIVERSITY OF BRITISH COLUMBIA 发明人 JEFFERIES, WILFRED A.;SETIADI, ALVERNIA FRANCESCA;DAVID, MURIEL D.;SEIPP, ROBYN P.;HARTIKAINEN, JENNIFER;GOPAUL, RAYSHAD
分类号 A61K38/45;A61K31/165;A61P37/02 主分类号 A61K38/45
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