发明名称 |
HAT ACETYLATION PROMOTERS AND USES OF COMPOSITIONS THEREOF IN PROMOTING IMMUNOGENICITY |
摘要 |
The invention provides processes and compositions for enhancing the immunogenicity of TAP-1 expression-deficient cells by increasing the presentation of MHC Class I surface molecules for detection by cytotoxic T-lymphocyte cells through increased TAP-1 expression, which comprises administering to the TAP-1 expression-deficient cells a TAP-1 expression increasing amount of a bio-acceptable substance that promotes transcription of TAP-1 gene in the cells to cause enhanced MHC Class I surface expression of the cells. The bio-acceptable substance may be a histone H3 deacetylase inhibitor such as trichostatin A, a transcriptional co-activator having intrinsic histone acetyl transferase activity or a histone acetyl transferase comprising at least one member of the CBP/p300 protein family. The process and compositions increase the immunogenicity of the target cells, e.g. tumor cells, to enhance their destruction by cytotoxic lymphocytes. |
申请公布号 |
CA2574531(C) |
申请公布日期 |
2016.10.25 |
申请号 |
CA20072574531 |
申请日期 |
2007.01.19 |
申请人 |
THE UNIVERSITY OF BRITISH COLUMBIA |
发明人 |
JEFFERIES, WILFRED A.;SETIADI, ALVERNIA FRANCESCA;DAVID, MURIEL D.;SEIPP, ROBYN P.;HARTIKAINEN, JENNIFER;GOPAUL, RAYSHAD |
分类号 |
A61K38/45;A61K31/165;A61P37/02 |
主分类号 |
A61K38/45 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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