2-Debenzoyl-2-acyl taxol derivatives and methods for making same

摘要

Compounds having the general formula: <IMAGE> wherein R1 is an alkyl or substituted alkyl; R2 is selected from the group consisting of H and C(O)Ra; R3 is selected from the group consisting of H, protecting groups, Rb, and C(O)Rb; R4 is selected from the group consisting of H and C(O)Rc, and wherein Ra, Rb, and Rc are independently selected from the group consisting of alkyls, substituted alkyls, alkenyls, alkynyls, aryls, and substituted aryls; provided that Ra is other than phenyl and 3-hydroxyphenyl.