| 摘要 |
<p>An improved electrospray ion production method and ion source designed to reduce overall gas load on the vacuum system and enhance the ion production and collection efficiencies. This ion source is for gas phase ion analysis of constituents dissolved in liquid solution comprising a needle (10) held at high electrical potential through which the said solution flows into a first chamber (1) maintained at reduced pressure, forming a highly charged liquid cone-jet. The highly charged liquid jet is steered, in the said first chamber, on-axis with an aperture into a second chamber (2) maintained at higher pressure than the said first chamber. The second chamber is heated and pressurized to facilitate desolvation of the of the solution droplets originating from the breakup of the highly charged jet, resulting in the production of gas phase ions by the electrospray ionization process. The said gas phase ions are then sampled and detected. Alternative reactions and/or inputs of energy via collision and/or radiation may occur in said second chamber to further facilitate ion production or fragmentation and may further enhance sample identification. This method and device may be useful in the implementation of liquid chromatography-mass spectrometry.</p> |
