BASE METAL CATALYZED BORYLATION OF ARENES AND AROMATIC HETEROCYCLES

摘要

In one aspect, cobalt complexes are described herein. In some embodiments, such cobalt complexes employ bis(phosphine) or bis(imine) ligand and are operable as catalysts for borylation of arenes and aromatic heterocycles.

主权项

1. A cobalt complex of Formula (I): wherein R1-R7 are independently selected from the group consisting of hydrogen, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyl-aryl and alkyl-heteroaryl, wherein the alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyl-aryl and alkyl-heteroaryl are optionally substituted with one or more substituents selected from the group consisting of (C1-C10)-alkyl, (C1-C10)-alkenyl, alkoxy, halo, hydroxy, C(O)OR10, NR11R12, wherein R10-R12 are independently selected from the group consisting of hydrogen, (C1-C10)-alkyl and (C1-C10)-alkenyl; and wherein R8 and R9 are independently selected from the group consisting of hydrogen, alkyl and alkoxy, wherein R8 and R9 may optionally form a substituted or unsubstituted cyclic structure or ring; and wherein E1 and E2 are independently selected from the group consisting of CR13, C(R13)2, O, S and NR14, wherein R13 and R14 are independently selected from the group consisting of hydrogen, alkyl, heteroalkyl, aryl and heteroaryl; and wherein G1 and G2 are independently selected from N and P; and wherein any two of R1-R7 that are vicinal to one another may optionally form a substituted or unsubstituted, saturated or unsaturated, cyclic structure or ring.