KEMISKA MELLANPRODUKTER FOR FRAMSTELLNING AV ESTRAR AV ALFA-AMINOMETYL-3-(HYDROXI ELLER HYDROXIMETYL)-4-HYDROXIBENSYLALKOHOLER GENOM REDUKTION AV MOTSVARANDE ESTERKETON

摘要

1298771 Sympathomimetic medicines STERLING DRUG Inc 20 March 1970 [1 April 1969] 13690/70 Heading A5B [Also in Division C2] Pharmaceutical compositions having sympathomimetic effects particularly bronchodilator activity being in conventional forms for oral or parenteral administration or in the preferred form as an aerosol inhalant preparation comprise an amino-ester of formulae I or II wherein R is hydrogen (only in formula II), alkyl having 1-4 carbon atoms, or cycloalkyl having 3-6 carbon atoms; R1 is hydrogen or alkyl having 1-3 carbon atoms; Y is an acyl member which is alkanoyl having 1-22 carbon atoms, alkenoyl having one or two double bonds and having 4-22 carbon atoms, O # cycloalkyl -C n H 2n -C- having a total of 4-10 carbon atoms of which 3-7 are ring carbon atoms in cycloalkyl and wherein n is zero, one, or two, phenoxyacetyl, naphthalenecarbonyl, pyridinecarbonyl, phenyl -C n H 2n O # -C- wherein n is zero, one or two and phenyl is unsubstituted or is substituted by 1-3 alkyl having 1-4 carbon atoms, alkoxy having 1-4 carbon atoms, halo, trifluoromethyl, dialkylamino having 2-8 carbon atoms, or alkanoylamine having 1-6 carbon atom groups; and Y1 and Y2 are the same or different and are hydrogen or one of the acyl members defined by Y, and wherein in Formula I at least one of Y and Y1 contains no less than four carbon atoms when R is tert-butyl or cycloalkyl and no less than seven carbon atoms when R is alkyl other than tertbutyl, and in Formula II at least one of Y and Y1 contains no less than four carbon atoms; or an acid-addition salt thereof and a suitable conventional carrier, and if necessary, a propellant.