New (2-substd. thiomethyl)-4-alkoxy-pyridine derivs. - useful as gastric acid secretion inhibitors for treating peptic ulcers

摘要

Pyridine derivs. of formula (I) and their pharmaceutically acceptable salts are new. R1 and R2=H; lower alkyl, alkoxy, haloalkyl or alkoxycarbonyl; COOH or halo; X=O, S or NR3; R3=H, lower alkyl, phenyl, benzyl or lower alkoxycarbonyl; Z=O(CH2)pR4 O(CH2)qR5, O(CH2)rO(CH2)sOR6, succinimido, 2-oxo-pyrrolidino, 1,1-dioxo thiomorpholino, S(O)tA, N(R8)CH2Ph or OR9; p=1-3; R4=H, lower alkyl, aryl or aralkyl; q= 1-3; R5=halo, alkoxycarbonyl, aryl or heteroaryl; r and s=1-5; R6=H or lower alkyl, t=0-2; A=a gp. of formula (a), lower alkyl, alkoxycarbonyl, pyridyl, furyl or (CH2)wAr; B=Nh, O or S; Ar=phenyl substd. by R7; R7=H, lwer alkyl, lower alkoxy or halo, w=0-1; R8= acetyoxy or lower alkyl; R9=H, lower alkyl or aryl; n=0-2; m=2-10, J and K=H or lower alkyl; and lower=1-6C; provided that when Z=OR9 and R9=lower alkyl, then m=3-10.